刘克印

刘克印

副教授

研究生导师

个人简介:


个人简历:

2014年7月毕业于复旦大学化学系,获博士学位,师从黄春辉院士、易涛教授,读博士学位期间主要围绕有机功能分子材料的设计及其应用进行研究。

2014年9月至2018年6月,在济南大学光功能材料与成像研究院工作,任副教授、青年龙山学者;期间主要围绕有机功能分子材料、新型荧光染料的构建及性能测试、小分子荧光探针的设计合成及生物应用、生物成像等的设计及其应用进行研究。

自2018年7月加入到齐鲁工业大学生物基功能材料与绿色造纸国家重点实验室,研究领域包含新型荧光染料的构建及生物应用;荧光探针的设计合成及生物应用、生物成像等;新型生物质分子组装材料的设计及应用。

研究方向:

新型荧光染料的构建及生物应用;荧光探针的设计合成及生物应用、生物成像等;新型生物质分子组装材料的设计及应用

主要业绩与成果:

讲授课程:《植物纤维水解技术》;

指导大学生开放实验;本科生创新实验;  

主持国家自然科学基金青年项目一项,以前2位获得国家发明专利授权多项。目前已在Nature Protocols, Angewandte Chemie International Edition,Biomaterials,Journal of Materials Chemistry B, Chemical Communication, Sensor and Actuator B等杂志发表学术论文20余篇。

在分子探针及分子识别方面,我们在分子探针的设计及应用方面取得了一系列重要的研究成果,在国际顶级期刊Nature系列杂志Nature Protocols上报道关于生物体内一氧化碳检测的研究成果;在国际具有重要影响力的学术期刊Angewandte Chemie International Edition (IF = 11.99) 上首次发表关于检测活动物体内的内源性一氧化碳的研究论文,解决了目前无法实现活体内一氧化碳检测的科学难题。利用过氧化氢及酸碱度双响应型荧光探针研究了生物内源性活性氧物种与生物体酸碱环境的关系,首次实现对碱性环境中过氧化氢的检测,该论文在材料及生物领域具有重要影响力的期刊Biomaterials (一区、IF = 8.40) 上发表。基于近红外荧光染料首次实现设计合成具有大Stokes shift的生物硫醇荧光探针,实现对内源性生物硫醇的检测(Journal of Materials Chemistry B)。利用双光子荧光染料设计合成新型细胞核仁靶向型硫化氢探针,成功检测细胞、组织及活体动物中的硫化氢信号分子(Sensor and Actuator B, IF = 5.4)。

在分子组装材料研究方面,利用分子组装过程构建了一系列环境响应型有机分子凝胶,获得可调控的光学响应及亲疏水界面材料(Journal of Materials Chemistry C)。利用凝胶材料的特有网格结构对药物释放进行跟踪研究。利用分子组装原理设计的DNA响应型有机分子材料具有光开关作用,能够可控调节与DNA的结合状态,在基因相关的疾病治疗方面具有重要意义(Chemical Communication, IF = 6.63)。

1.     Keyin Liu ⃰, Yunling Chen, Hui Sun, Shoujuan Wang and Fangong Kong ⃰, Construction of a novel near-infrared fluorescent probe with multiple fluorescence emission and its application for SO2 derivative detection in cells and living zebrafish, Journal of Materials Chemistry B, 2018, 6, 7060-7065. (一区、IF = 4.54)

2.     Keyin Liu, Xiuqi Kong, Yanyan Ma, Weiying Lin ⃰ , Preparation of a highly sensitive Nile Red-Pd-based near-infrared fluorescent probe and its application for tracking endogenous CO in living zebrafish embryos and mouse organs. Nature Protocols, 2018, 13, 1020-1033. (一区、IF = 10.03).

3.     Keyin Liu, Xiuqi Kong, Yanyan Ma, Weiying Lin ⃰ , Rational design of a robust fluorescent probe for detecting endogenous carbon monoxide in living zebrafish embryos and mouse tissues. Angewandte Chemie International Edition, 2017, 56: 13489-13492. (一区、IF = 11.99)

4.     Keyin Liu, Huiming Shang, Mingguang Ren, Weiying Lin ⃰ , A novel red light emissive two-photon fluorescent probe for hydrogen sulfide (H2S) in nucleolus region and its application for H2S detection in zebrafish and living mice, Sensors and Actuators B-Chemical, 2018, 256: 342-350. (一区、IF = 5.40)

5.     Keyin Liu, Huiming Shang, Xiuqi Kong, Weiying Lin ⃰ , A novel near-infrared fluorescent probe with a large Stokes shift for biothiol detection and application in in vitro and in vivo fluorescence imaging. Journal of Materials Chemistry B, 2017, 5: 3836-3841. (一区、IF = 4.54)

6.     Keyin Liu, Huiming Shang, Xiuqi Kong, Mingguang Ren, Jian-Yong Wang, Yong Liu, Weiying Lin ⃰ , A novel near-infrared fluorescent probe for H2O2 in alkaline environment and the application for H2O2 imaging in vitro and in vivo. Biomaterials, 2016, 100: 162-171. (一区、IF = 8.40)

7.     Keyin Liu, Huiming Shang, Fangfang Meng, Yong Liu, Weiying Lin ⃰ , A novel near-infrared fluorescent platform with good photostability and the application for a reaction-based Cu2+ probe in living cells. Talanta, 2016, 147: 193-198. (二区、IF = 4.16)

8.     Keyin Liu, Zhan-Rong Liu, Xiuqi Kong, Yuan-Qiang Sun, Weiying Lin ⃰ , A smart near-infrared fluorescent probe for H2O2 in alkaline environment and H2O2 imaging in vitro and in vivo. Macrophage, 2016, 3: e1398.

9.     Keyin Liu, Ying Wen, Ting Shi, Yi Li, Fuyou Li, Yi-lei Zhao, Chunhui Huang, Tao Yi ⃰, DNA gated photochromism and fluorescent switch in a thiazole orange modified diarylethene, Chemical Communications, 2014, 9141-9144. ((一区、IF = 6.32).

10.   Keyin Liu, Luyan Meng, Shuli Mo, Mingming Zhang, Yueyuan Mao, Xinhua Cao, Chunhui Huang, Tao Yi ⃰, Colour change and luminescence enhancement in a cholesterol-based terpyridyl platinum metallogel via sonication, Journal of Materials Chemistry C 2013, 1: 1753-1762. (一区、IF = 5.26) 

11.   Huiming Shang, Keyin Liu, Weiying Lin ⃰, Construction of a novel ratiometric near-infrared fluorescent probe for SO2 derivatives and its application for biological imaging. Analytical Methods, 2017, 9: 3790-3794.

12.   Ying Wen, Keyin Liu, Huiran Yang, Yi Liu, Liang Chen, Zhonghuan Liu, Chunhui Huang, Tao Yi ⃰, Mitochondria-directed fluorescent probe for the detection of hydrogen peroxide near mitochondrial DNA. Analytical Chemistry, 2015, 87: 10579-10584.

13.   Ying Wen, Keyin Liu, Huiran Yang, Yi Li, Haichuang Lan, Yi Liu, Xinyu Zhang, Tao Yi ⃰, A highly sensitive ratiometric fluorescent probe for the detection of cytoplasmic and nuclear hydrogen peroxide. Analytical Chemistry, 2014, 86, 9970-9976.

14.   Yueyuan Mao, Keyin Liu, Guanglei Lv, Ying Wen, Xingjun Zhu, Haichuang Lan, Tao Yi ⃰, CB[8] gated photochromism of a diarylethene derivative containing thiazole orange groups. Chemical Communications, 2015, 51: 6667-6670.

15.   Yueyuan Mao, Keyin Liu, Liang Chen, Xinhua Cao, Tao Yi ⃰, A programmed DNA marker based on bis(4-ethynyl-1,8-naphthalimide) and three-methane-bridged thiazole orange. Chemistry-a European Journal, 2015, 21: 16623-16630.

16.   Yueyuan Mao, Keyin Liu, Luyan Meng, Liang Chen, Liming Chen, Tao Yi ⃰, Solvent induced helical aggregation in the self-assembly of cholesterol tailed platinum complexes. Soft Matter 2014, 10, 7615-7622. (IF = 3.9)

17.   吕光磊, 刘克印, 孟路燕, 易涛. 二芳乙烯荧光开关材料及其应用进展[J]. 影像科学与光化学;2014,32,28-42.

18.   刘克印; 孟路燕; 曹新华; 张明明; 易涛; 超声调控的三联吡啶铂化合物凝胶[A]; 中国化学会第28届学术年会, 2012年4月12-15日。



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